Shaw Lab at UNL Chemistry
Cutting-edge bioanalytical technologies and methods to enable and inform chemical and structural biology approaches
April 2026
Our new experimental approach to characterization of ribosome heterogeneity was published in JACS!
Sachin's paper demonstrates how the combination of top-down proteomics and native mass spectrometry reveal unprecedented detail in ribosomal protein heterogeneity. Additionally, we established the first approach capable of measuring proteoform-resolved relative interaction strengths within large, heterogeneous molecular machines. This provides a direct link between proteoforms and biological function, e.g., translation regulation!
January 2026
Lasini's paper on the effects of supercharging on top-down antibody characterization was published
Fall 2025
Chahat, Deshani, and Salina joined the group!
July 2025
NIH R35 was funded!
"Ion laboratory for the elucidation of macromolecular assembly heterogeneity"
Fall 2024
Lasini joined the group!
July 2024
Thermo Fisher Scientific Orbitrap Exploris 480 mass spectrometer and Vanquish Neo UHPLC installed in the Shaw Lab!
June 2024
ASMS Conference in Anaheim, CA
Sachin presented very nice results for native MS characterization of E. coli ribosomes!
September 2023
Mashiyat and Sachin are the first students to join the Shaw Lab!
